{"id":38329,"date":"2025-05-14T13:48:18","date_gmt":"2025-05-14T13:48:18","guid":{"rendered":"https:\/\/ikimisli.tr\/?p=38329"},"modified":"2025-05-14T13:48:18","modified_gmt":"2025-05-14T13:48:18","slug":"yeni-arastirma-kanser-riski-dogmadan-belirlenebilir","status":"publish","type":"post","link":"https:\/\/ikimisli.tr\/index.php\/2025\/05\/14\/yeni-arastirma-kanser-riski-dogmadan-belirlenebilir\/","title":{"rendered":"Yeni ara\u015ft\u0131rma: Kanser riski do\u011fmadan belirlenebilir"},"content":{"rendered":"<p>Ara\u015ft\u0131rmac\u0131lar, epigenetik sistemler \u00fczerinde \u00e7al\u0131\u015farak, genlerin nas\u0131l programland\u0131\u011f\u0131n\u0131 ve bu s\u00fcre\u00e7lerin kanser riskini nas\u0131l etkiledi\u011fini inceledi. Bilhassa TRIM28 proteini, genlerin a\u00e7\u0131l\u0131p kapanmas\u0131n\u0131 denetim eden bir epigenetik fakt\u00f6r olarak dikkat \u00e7ekti.<\/p>\n<p>\u00c7al\u0131\u015fmada genetik olarak modifiye edilmi\u015f fareler kullan\u0131ld\u0131 ve bu farelerde iki farkl\u0131 epigenetik durum tespit edildi. Bu gen programlama modellerinin g\u00fcc\u00fc, farelerin ilerleyen ya\u015flarda kansere yakalanma riskini direkt etkiledi.<\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar, genetik olarak t\u0131pk\u0131 olan farelerin bile farkl\u0131 geli\u015fim s\u00fcre\u00e7lerinden ge\u00e7ebildi\u011fini ve bunun kanser riskini de\u011fi\u015ftirdi\u011fini vurgulad\u0131. Lakin, bu epigenetik de\u011fi\u015fikliklere neyin neden oldu\u011fu \u015fimdi kesin olarak bilinmiyor.<\/p>\n<p>Ara\u015ft\u0131rma, yaln\u0131zca kanser riskinin de\u011fil, t\u0131pk\u0131 vakitte hangi cins kanserin geli\u015fece\u011finin de epigenetik durumla irtibatl\u0131 oldu\u011funu ortaya koydu.<\/p>\n<ul>\n<li>D\u00fc\u015f\u00fck riskli epigenetik durumda geli\u015fen kanserler daha \u00e7ok l\u00f6semi yahut lenfoma \u00fczere s\u0131v\u0131 t\u00fcm\u00f6rler oldu.<\/li>\n<li>Y\u00fcksek riskli epigenetik durumda ise akci\u011fer yahut prostat kanseri \u00fczere kat\u0131 t\u00fcm\u00f6rler daha s\u0131k g\u00f6r\u00fcld\u00fc.<\/li>\n<\/ul>\n<p>Bu bulgu, epigenetik sistemlerin kanserin tipini de etkileyebilece\u011fini g\u00f6steriyor.<\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar, bu epigenetik farkl\u0131l\u0131klar\u0131n rastgele mi olu\u015ftu\u011fu, yoksa d\u0131\u015f etkenlerden mi kaynakland\u0131\u011f\u0131 konusunda kesin bir sonuca ula\u015famad\u0131. Lakin, daha evvel yap\u0131lan kimi \u00e7al\u0131\u015fmalar, anne karn\u0131nda alkol yahut toksinlere maruz kalman\u0131n ilerleyen ya\u015flarda kanser riskini art\u0131rabilece\u011fini g\u00f6stermi\u015fti.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/ikimisli.tr\/wp-content\/uploads\/2025\/05\/yeni-arastirma-kanser-riski-dogmadan-belirlenebilir-0-mnBHeNe4.webp\"\/><\/p>\n<p>Van Andel Enstit\u00fcs\u00fc Epigenetik Merkezi Y\u00f6neticisi J. Andrew Pospisilik, \u201c\u00c7o\u011fu kanserin genetik mutasyonlarla ili\u015fkili oldu\u011fu d\u00fc\u015f\u00fcn\u00fcl\u00fcyor ve bu y\u00fczden geli\u015fim s\u00fcrecinin kanser riskini nas\u0131l \u015fekillendirdi\u011fine pek odaklan\u0131lmad\u0131. Lakin bu ara\u015ft\u0131rma bu anlay\u0131\u015f\u0131 de\u011fi\u015ftiriyor\u201d dedi.<\/p>\n<p>Bu yeni bulgular, kanserin temel nedenlerine dair yesyeni bir ara\u015ft\u0131rma alan\u0131 a\u00e7abilir. Epigenetik d\u00fczeneklerin daha yeterli anla\u015f\u0131lmas\u0131, kanser te\u015fhisi ve tedavisinde yeni yakla\u015f\u0131mlar geli\u015ftirilmesine yard\u0131mc\u0131 olabilir.<\/p>\n<p>Van Andel Enstit\u00fcs\u00fc&#8217;nden Ilaria Panzeri, \u201cHerkesin kansere yakalanma ihtimali farkl\u0131d\u0131r, lakin bunu s\u0131rf \u2018k\u00f6t\u00fc \u015fans\u2019 olarak de\u011ferlendiremeyiz\u201d dedi. \u201cK\u00f6t\u00fc baht\u0131 tedavi edemezsiniz, lakin epigenetik sistemleri ama\u00e7 alarak kanser tedavisi geli\u015ftirebilirsiniz.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yeni bir ara\u015ft\u0131rmaya nazaran, kanser riski do\u011fmadan evvel \u015fekillenebilir. ABD\u2019deki Van Andel Enstit\u00fcs\u00fc taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma, anne karn\u0131ndaki geli\u015fim s\u00fcrecinin ilerleyen ya\u015flarda kansere yakalanma ihtimalini art\u0131rabilece\u011fini yahut azaltabilece\u011fini ortaya koydu.<\/p>\n","protected":false},"author":1,"featured_media":38330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[2093,4075,3038,710],"class_list":["post-38329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-arastirma","tag-epigenetik","tag-gen","tag-kanser"],"_links":{"self":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/38329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/comments?post=38329"}],"version-history":[{"count":1,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/38329\/revisions"}],"predecessor-version":[{"id":38332,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/38329\/revisions\/38332"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media\/38330"}],"wp:attachment":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media?parent=38329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/categories?post=38329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/tags?post=38329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}