{"id":53816,"date":"2025-07-02T19:12:12","date_gmt":"2025-07-02T19:12:12","guid":{"rendered":"https:\/\/ikimisli.tr\/?p=53816"},"modified":"2025-07-02T19:12:12","modified_gmt":"2025-07-02T19:12:12","slug":"bilim-insanlari-yaslanmayi-engellemek-icin-anahtar-geni-buldu","status":"publish","type":"post","link":"https:\/\/ikimisli.tr\/index.php\/2025\/07\/02\/bilim-insanlari-yaslanmayi-engellemek-icin-anahtar-geni-buldu\/","title":{"rendered":"Bilim insanlar\u0131 ya\u015flanmay\u0131 engellemek i\u00e7in anahtar geni buldu"},"content":{"rendered":"

Osaka \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar, AP2A1 isimli protein alt \u00fcnitesinin, ya\u015flanm\u0131\u015f h\u00fccrelerin e\u015fsiz yap\u0131sal tertibinde k\u0131ymetli bir rol oynayabilece\u011fini tespit etti. AP2A1’in bask\u0131lanmas\u0131n\u0131n h\u00fccrelerde ya\u015flanmay\u0131 bilakis \u00e7evirdi\u011fi, art\u0131\u015f\u0131n\u0131n ise ya\u015flanmay\u0131 h\u0131zland\u0131rd\u0131\u011f\u0131 kaydedildi.<\/p>\n

\u00c7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 Pirawan Chantachotikul, \u201cYa\u015flanm\u0131\u015f h\u00fccrelerin b\u00fcy\u00fck boyutlar\u0131n\u0131 nas\u0131l koruduklar\u0131n\u0131 anlam\u0131\u015f de\u011filiz. Bir farkl\u0131 ipucu, gerilim liflerinin ya\u015flanm\u0131\u015f h\u00fccrelerde, gen\u00e7 h\u00fccrelere nazaran \u00e7ok daha kal\u0131n olmas\u0131. Bu da bu liflerdeki proteinlerin, h\u00fccrelerin b\u00fcy\u00fck boyutlar\u0131n\u0131 desteklemede yard\u0131mc\u0131 oldu\u011funu g\u00f6steriyor\u201d dedi.<\/p>\n

<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, bu m\u00fcmk\u00fcnl\u00fc\u011f\u00fc incelemek i\u00e7in AP2A1\u2019i (Adapt\u00f6r Protein Kompleksi 2, Alfa 1 Alt Birimi) inceledi. AP2A1, ya\u015flanm\u0131\u015f h\u00fccrelerde, bilhassa fibroblastlar ve epitel h\u00fccrelerinde, gerilim liflerinde artm\u0131\u015f bir formda bulunan bir protein. Bilim insanlar\u0131, AP2A1 tabirini ya\u015fl\u0131 h\u00fccrelerde ortadan kald\u0131rarak ve gen\u00e7 h\u00fccrelerde \u00e7ok g\u00f6stererek, ya\u015flanmaya benzeri davran\u0131\u015flar\u0131 incelediler.<\/p>\n

YA\u015eLANMAYI B\u0130LAK\u0130S \u00c7EV\u0130REB\u0130L\u0130R<\/strong><\/p>\n

K\u0131demli m\u00fcellif Shinji Deguchi, \u201cSonu\u00e7lar \u00e7ok de\u011fi\u015fikti. Ya\u015fl\u0131 h\u00fccrelerde AP2A1\u2019in bask\u0131lanmas\u0131, ya\u015flanmay\u0131 bilakis \u00e7evirerek h\u00fccresel yenilenmeyi te\u015fvik ederken, gen\u00e7 h\u00fccrelerde AP2A1 \u00e7ok s\u00f6z\u00fc, ya\u015flanmay\u0131 h\u0131zland\u0131rd\u0131\u201d diye konu\u015ftu.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar ayr\u0131yeten, AP2A1\u2019in, h\u00fccrelerin etraflar\u0131ndaki kolajen matrise tutunmalar\u0131na yard\u0131mc\u0131 olan bir protein olan integrin \u03b21 ile yak\u0131ndan ili\u015fkilendirildi\u011fini ve her iki proteinin de h\u00fccre i\u00e7indeki gerilim lifleri boyunca hareket etti\u011fini buldu. A\u00e7\u0131klamada, integrin \u03b21\u2019in fibroblastlarda h\u00fccre-alt katman yap\u0131\u015fmalar\u0131n\u0131 g\u00fc\u00e7lendirdi\u011fi ve bu durumun, ya\u015flanm\u0131\u015f h\u00fccrelerin kal\u0131nla\u015fan yahut y\u00fckselen yap\u0131lar\u0131n\u0131n nedenini a\u00e7\u0131klayabilece\u011fi bildirildi.<\/p>\n

<\/p>\n

Chantachotikul, \u201cBulgular\u0131m\u0131z, ya\u015flanm\u0131\u015f h\u00fccrelerin, geni\u015flemi\u015f gerilim lifleri boyunca AP2A1 ve integrin \u03b21\u2019in hareketiyle, h\u00fccre d\u0131\u015f\u0131 matrise g\u00fc\u00e7lendirilmi\u015f yap\u0131\u015fma yoluyla b\u00fcy\u00fck boyutlar\u0131n\u0131 korudu\u011funu g\u00f6steriyor\u201d s\u00f6zlerini kulland\u0131.<\/p>\n

Ara\u015ft\u0131rma tak\u0131m\u0131, bu \u00e7al\u0131\u015fman\u0131n ya\u015fl\u0131l\u0131kla ili\u015fkilendirilen hastal\u0131klar i\u00e7in yeni bir tedavi gayesi sa\u011flayabilece\u011fini de s\u00f6yledi.<\/p>\n","protected":false},"excerpt":{"rendered":"

Bilim insanlar\u0131, h\u00fccresel seviyede ya\u015flanmay\u0131 bilakis \u00e7evirebilecek anahtar proteini ke\u015ffetti.<\/p>\n","protected":false},"author":1,"featured_media":53817,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[3335,4661,3625,7369,7368],"class_list":["post-53816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-hucre","tag-hucrelerin","tag-protein","tag-yaslanmayi","tag-yaslanmis"],"_links":{"self":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/53816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/comments?post=53816"}],"version-history":[{"count":1,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/53816\/revisions"}],"predecessor-version":[{"id":53820,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/53816\/revisions\/53820"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media\/53817"}],"wp:attachment":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media?parent=53816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/categories?post=53816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/tags?post=53816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}