Almanya merkezli cilt bak\u0131m \u015firketi Beiersdorf AG\u2019den ara\u015ft\u0131rmac\u0131lar\u0131n y\u00fcr\u00fctt\u00fc\u011f\u00fc \u00e7al\u0131\u015fmada, laboratuvar ortam\u0131nda \u00f6zel bir 3 boyutlu insan cildi modeli olu\u015fturuldu. Bilim insanlar\u0131 bu modele gen\u00e7 bireylerden al\u0131nan kan serumu ekledi. Fakat gen\u00e7 serum tek ba\u015f\u0131na besbelli bir tesir g\u00f6stermedi. As\u0131l fark, sisteme kemik ili\u011fi h\u00fccreleri eklendi\u011finde ortaya \u00e7\u0131kt\u0131.<\/p>\n
Gen\u00e7 serumu ile kemik ili\u011fi h\u00fccrelerinin etkile\u015fimi sonucu, cilt h\u00fccrelerinde ya\u015flanma ayk\u0131r\u0131s\u0131 sinyaller tespit edildi. Bu sinyaller ortas\u0131nda DNA metilasyonu, h\u00fccre b\u00f6l\u00fcnmesi ve metabolik aktivite art\u0131\u015f\u0131 \u00fczere, biyolojik ya\u015f\u0131n azalmas\u0131yla ili\u015fkilendirilen g\u00f6stergeler yer al\u0131yor.<\/p>\n
Ara\u015ft\u0131rmada, gen\u00e7 kanla etkile\u015fen kemik ili\u011fi h\u00fccrelerinin salg\u0131lad\u0131\u011f\u0131 55 farkl\u0131 protein belirlendi. Bunlardan 7 tanesi, h\u00fccre yenilenmesi ve kolajen \u00fcretimi \u00fczere gen\u00e7 ciltle kontakl\u0131 s\u00fcre\u00e7lerde direkt rol oynuyor. Bu proteinler, gen\u00e7 kan\u0131n ya\u015flanma \u00fczerindeki tesirini a\u00e7\u0131klamak ismine kilit birer aday olarak bedellendiriliyor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, bu bulgular\u0131n sadece laboratuvar ortam\u0131ndaki cilt h\u00fccrelerinde ge\u00e7erli oldu\u011funu vurguluyor. Yani bu tesirin be\u015ferler \u00fczerindeki ger\u00e7ek sonu\u00e7lar\u0131 \u015fimdi test edilmedi. Lakin elde edilen datalar, gelecekteki klinik uygulamalar i\u00e7in umut vaat ediyor.<\/p>\n
\u201cCilt, ya\u015flanman\u0131n en erken belirtilerini g\u00f6steren ve genel s\u0131hhat durumunu yans\u0131tan en b\u00fcy\u00fck organ\u0131m\u0131z\u201d diyen ara\u015ft\u0131rma tak\u0131m\u0131, cildin ya\u015flanma \u00e7al\u0131\u015fmalar\u0131nda neden \u00fclk\u00fc bir model oldu\u011funu da a\u00e7\u0131kl\u0131yor.<\/p>\n
\u00c7al\u0131\u015fman\u0131n yay\u0131mland\u0131\u011f\u0131 Aging isimli bilimsel mecmuada, ara\u015ft\u0131rmac\u0131lar \u015fu s\u00f6zleri kullan\u0131yor:<\/p>\n
\u201cGen\u00e7le\u015ftirici tesire sahip olabilecek birka\u00e7 protein belirledik. Bu proteinlerin sistematik ya\u015flanma tersi etkilerdeki rollerini daha ileri \u00e7al\u0131\u015fmalarla do\u011frulamak gerekiyor.\u201d<\/em><\/p>\n Bilim d\u00fcnyas\u0131nda, ya\u015flanman\u0131n b\u00fcsb\u00fct\u00fcn durdurulamayaca\u011f\u0131 lakin kimi tesirlerinin geri \u00e7evrilebilece\u011fi niyeti giderek g\u00fc\u00e7 kazan\u0131yor. Ya\u015flanan d\u00fcnya n\u00fcfusu g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, bu \u00e7e\u015fit ara\u015ft\u0131rmalar sadece estetik de\u011fil, ya\u015fl\u0131l\u0131k kaynakl\u0131 hastal\u0131klar\u0131n \u00f6nlenmesi a\u00e7\u0131s\u0131ndan da b\u00fcy\u00fck de\u011fer ta\u015f\u0131yor.<\/p>\n \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":" Gen\u00e7 bireylerden al\u0131nan kan\u0131n ya\u015flanmay\u0131 bilakis \u00e7evirebilece\u011fi fikri, uzun y\u0131llard\u0131r hem bilimsel hem de tan\u0131nan k\u00fclt\u00fcrde tart\u0131\u015f\u0131lan bir husus. Yeni bir ara\u015ft\u0131rma, bu arg\u00fcmana bilimsel bir temel kazand\u0131rarak, gen\u00e7 kan\u0131n insan cilt h\u00fccrelerini nas\u0131l gen\u00e7le\u015ftirebildi\u011fini g\u00f6sterdi.<\/p>\n","protected":false},"author":1,"featured_media":75775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[2093,2651,525,1424,7071],"class_list":["post-75774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-arastirma","tag-cilt","tag-etki","tag-genc","tag-yaslanma"],"_links":{"self":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/75774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/comments?post=75774"}],"version-history":[{"count":1,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/75774\/revisions"}],"predecessor-version":[{"id":75776,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/75774\/revisions\/75776"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media\/75775"}],"wp:attachment":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media?parent=75774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/categories?post=75774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/tags?post=75774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}