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<\/p>\nTayvanl\u0131 bilim insanlar\u0131, tatl\u0131lar\u0131n vazge\u00e7ilmez baharat\u0131na dair enteresan bir ara\u015ft\u0131rma yapt\u0131. Tar\u00e7\u0131nda bulunan sinnamik asidin bedende metabolize edilmesiyle ortaya \u00e7\u0131kan sodyum benzoat\u0131n, hafif Alzheimer hastalar\u0131nda bili\u015fsel fonksiyonu g\u00fczelle\u015ftirebilece\u011fini ortaya koydular. \u00c7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 Translational Psychiatry mecmuas\u0131nda yay\u0131mland\u0131.<\/p>\n
\u00c7OK HASTA \u00dcZER\u0130NDE DENEND\u0130<\/b><\/p>\n
Ara\u015ft\u0131rma, ya\u015flar\u0131 50 ile 100 ortas\u0131nda de\u011fi\u015fen ve hafif evre Alzheimer tan\u0131s\u0131 konmu\u015f 149 hasta \u00fczerinde ger\u00e7ekle\u015ftirildi. \u0130\u015ftirak\u00e7ilerin kanlar\u0131nda amiloid-beta ismi verilen ve hastal\u0131\u011f\u0131n temel nedeni olarak bilinen proteinin y\u00fcksek d\u00fczeyde bulundu\u011fu belirlendi.<\/p>\n
Hastalar 24 hafta boyunca d\u00f6rt k\u00fcmeye ayr\u0131larak plasebo\u00a0 500 mg, 750 mg ya da 1.000 mg sodyum benzoat kaps\u00fclleri ald\u0131.<\/p>\n
<\/p>\n
\u00d6zellikle 750 mg ve 1.000 mg alan k\u00fcmelerde, amiloid-beta 1-40 ve toplam amiloid-beta d\u00fczeylerinde bariz azalma g\u00f6zlendi.<\/p>\n
Y\u00fcksek ba\u015flang\u0131\u00e7 amiloid-beta 1-42 d\u00fczeyine sahip hastalar, bili\u015fsel testlerde daha b\u00fcy\u00fck ilerleme kaydetti.<\/p>\n
Plasebo k\u00fcmesinde ise birebir g\u00fczelle\u015fme g\u00f6r\u00fclmedi. Tedavi m\u00fchletince sodyum benzoat\u0131n plaseboya emsal bir yan tesir profili sergiledi\u011fi yani inan\u00e7l\u0131 ve tolere edilebilir oldu\u011fu bildirildi.<\/p>\n
ETK\u0130S\u0130 TESTLERLE KANITLANDI<\/b><\/p>\n
Kat\u0131l\u0131mc\u0131lar\u0131n bili\u015fsel performans\u0131, Alzheimer Hastal\u0131\u011f\u0131 K\u0131ymetlendirme \u00d6l\u00e7e\u011fi-Bili\u015fsel Alt \u00d6l\u00e7ek (ADAS-Cog) ile \u00f6l\u00e7\u00fcld\u00fc. Daha d\u00fc\u015f\u00fck puan\u0131n daha g\u00fczel fonksiyonu g\u00f6sterdi\u011fi bu testte, y\u00fcksek doz alan hastalar 24 hafta sonunda manal\u0131 derecede daha yeterli sonu\u00e7lar verdi.<\/p>\n
TAR\u00c7IN BU KADAR TES\u0130RL\u0130 M\u0130?<\/b><\/p>\n
Tar\u00e7\u0131n\u0131n i\u00e7erisinde bulunan do\u011fal sinnamik asit, bedende antioksidan \u00fczere \u00e7al\u0131\u015f\u0131r. Bu da d\u0131\u015f etkenlerden \u00f6t\u00fcr\u00fc bedene girip ziyan veren molek\u00fcllerin gerilimini azaltmaya yard\u0131mc\u0131 olur. \u0130ltihab\u0131 d\u00fc\u015f\u00fcr\u00fcr ve ins\u00fclin s\u00fcrece kapasitesini korur.\u00a0<\/p>\n
DNA hasar\u0131n\u0131 engelledi\u011fini \u00fczere ya\u011f par\u00e7alanmas\u0131n\u0131 takviyeler ve enzimleri aktive eder. Bu da obeziteyle gayret etmesine fayda. Ama yap\u0131lan \u00e7al\u0131\u015fmada, kullan\u0131lan sodyum benzoat farmas\u00f6tik dozlarda verildi. Tar\u00e7\u0131nda do\u011fal olarak bulunan \u00f6l\u00e7\u00fc bu d\u00fczeylerin \u00e7ok alt\u0131nda. Yani s\u0131rf baharata g\u00fcvenerek t\u0131pk\u0131 etkiyi sa\u011flamak m\u00fcmk\u00fcn de\u011fil.<\/p>\n
ALZHE\u0130MER TEDAV\u0130S\u0130NDE YEN\u0130 UMUT<\/b><\/p>\n
Alzheimer hastal\u0131\u011f\u0131 i\u00e7in halihaz\u0131rda onayl\u0131 kimi intraven\u00f6z tedaviler, amiloid-beta plaklar\u0131n\u0131 ama\u00e7 alarak bili\u015fsel gerilemeyi yava\u015flatabiliyor. Lakin bu ila\u00e7lar y\u00fcksek maliyet, s\u0131k inf\u00fczyon ihtiyac\u0131 ve beyin \u015fi\u015fmesi yahut kanama riski \u00fczere de\u011ferli dezavantajlar ta\u015f\u0131yor.<\/p>\n
Bu nedenle uzmanlar, a\u011f\u0131zdan al\u0131nabilen, inan\u00e7l\u0131 ve kolay uygulanabilir sodyum benzoat\u0131n “gelece\u011fin amiloid-beta azalt\u0131c\u0131 ilac\u0131” olabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyor.<\/p>\n
\u00d6NCEK\u0130 BULGULAR NEYD\u0130?<\/b><\/p>\n
Sodyum benzoat\u0131n yararlar\u0131 daha evvel de ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131.<\/p>\n
2016’da Chicago Rush \u00dcniversitesi\u2019nden Dr. Kalipada Pahan, tar\u00e7\u0131n\u0131n \u00f6\u011frenme ve haf\u0131zay\u0131 destekleyebilece\u011fini \u00f6ne s\u00fcrd\u00fc.<\/p>\n
Fare deneylerinde tar\u00e7\u0131n t\u00fcketimi, beynin haf\u0131za merkezi olan hipokamp\u00fcsteki ziyanl\u0131 de\u011fi\u015fiklikleri bilakis \u00e7evirdi.<\/p>\n
2023\u2019te \u00c7in ve Brezilya\u2019dan gruplar, sodyum benzoat\u0131n Alzheimer hastalar\u0131n\u0131n kan\u0131ndaki amiloid-beta ve tau protein birikimini azaltt\u0131\u011f\u0131n\u0131 raporlad\u0131.<\/p>\n
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"
Alzheimer ara\u015ft\u0131rmalar\u0131nda heyecan verici bir geli\u015fme, g\u00fcnl\u00fck hayat\u0131m\u0131z\u0131n tan\u0131d\u0131k bir baharat\u0131ndan geldi. Mutfaklar\u0131m\u0131zdan eksik olmayan bu baharat Alzheimer’\u0131 bitirecek cinsten. \u0130\u015fte ara\u015ft\u0131rmaya dair ayr\u0131nt\u0131lar<\/p>\n","protected":false},"author":1,"featured_media":81802,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[660,6130,519,9225],"class_list":["post-81801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-alzheimer","tag-bilissel","tag-hasta","tag-tarcin"],"_links":{"self":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/81801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/comments?post=81801"}],"version-history":[{"count":1,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/81801\/revisions"}],"predecessor-version":[{"id":81804,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/posts\/81801\/revisions\/81804"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media\/81802"}],"wp:attachment":[{"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/media?parent=81801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/categories?post=81801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ikimisli.tr\/index.php\/wp-json\/wp\/v2\/tags?post=81801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}